Composition: 1 capsule contains: Active ingredient: buy halotestin – 50 mg Excipients: lactose monohydrate, kroskarmelezy sodium, povidone COA, colloidal silicon dioxide, magnesium stearate, indigotine (E 132), iron oxide yellow (E-172), oxide titanium (E-171), gelatin.
Description : Hard gelatin capsules (size №1), consisting of opaque white opaque green body and cap. Capsules containing granules yellow odorless.
Pharmacotherapeutic group : Anti-inflammatory agent with symptom-modifying effect in slow motion ATX Code M01AH21
PHARMACOLOGICAL PROPERTIES Pharmacodynamics buy halotestin synthesis and inhibits the activity of interleukin – 1 (IL-1), which plays an important role in inflammation, and the subsequent degradation of cartilage destruction in osteoarthritis. Furthermore, buy halotestin inhibits the effect of other cytokines that cause inflammation, including IL-6, TNF α . buy halotestin also inhibits the formation of metalloproteinases (collagenase, elastase) are involved in the process of cartilage damage. Prolonged use of buy halotestin stimulates proteoglycan synthesis and does not affect the synthesis of prostaglandins.
Following oral administration of buy halotestin is rapidly absorbed from the gastrointestinal tract and is completely deacetylated to rhein. Simultaneous administration of the drug with food increases the bioavailability by 25%. The maximum concentration (Cmax) of rhein in plasma is reached after 144 minutes. Plasma half-life period of 255 minutes. Rhein Contact albumin virtually 100%. In single dose up to 50 mg Cmax of 3.15 mg / l. With multiple dose Cmax of the drug is increased due to the accumulation of the drug. Rhine excreted by the kidneys in unchanged form (20%) and a glucuronide (60%) and sulphate (20%). Rhine crosses the placental and blood-brain barriers.
Primary and secondary osteoarthritis.
Individual intolerance to the drug, or high sensitivity to antrahionovym drugs (such as laxatives). Children’s age (18 years). Pregnancy, lactation. Be wary of
patients with irritable bowel lower divisions drug is given only in special cases. It should be careful to use the drug in the presence of chronic renal failure.
DOSAGE AND ADMINISTRATION
The standard intake: 1 capsule 2 times a day (morning and evening, after a meal). The capsules should be swallowed whole without chewing, and drink water. The effect of the treatment can be expected after 2-4 weeks. Artrodarin taken continuously for a long time or courses lasting at least 4 months.
In case of hypersensitivity to the drug may experience allergic reactions to varying degrees.
In the initial period of the drug may temporarily be a phenomenon on the part of the digestive system: diarrhea, nausea, vomiting, abdominal pain. In this case, the dosage can be reduced to one capsule a day.
In the treatment may take place intense staining urine from yellow to brown (depending on pH), which does not require dose reduction (cancellation) of the drug.
If overdose is possible diarrhea, weakness. In case of overdose or accidental medication children should consult a doctor. Treatment is symptomatic.
Interaction with other drugs
Artrodarin advised not to take along with substances that affect the quality of the intestinal contents and emptying speed (for example, a large amount of fiber). Antacids reduce the buy halotestin absorption of the drug. At simultaneous reception with antibiotics or chemotherapeutic drugs affecting the intestinal microflora, may increase the frequency of adverse events on the part of the intestine.
The duration of treatment depending on the result achieved might be prolonged. In the period prior to the development of therapeutic effect Artrodarin can be taken together with analgesics and non-steroidal anti-inflammatory drugs. A periodic monitoring blood counts, liver enzymes, urinalysis. When renal function deterioration in the physician should reduce the dose of the drug.
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