Each capsule contains: Active ingredient : diacerein 50.0 mg Excipients : lactose monohydrate, povidone, croscarmellose sodium, sodium lauryl sulfate, magnesium stearate, colloidal silicon dioxide Hard gelatin capsule (body) : gelatin, water, brilliant blue dye, titanium dioxide The dye FLOXIN, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl Hard gelatin capsule (cap) : gelatin, water, brilliant blue dye, titanium dioxide, quinoline yellow dye, the dye in FLOXIN, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate
Description : Hard gelatin halotestin side effects number «2», with the inscription “Micro / Micro” consisting of a gray body and blue cap, the contents of the capsule yellow granular powder.
Pharmacotherapeutic group : Non-steroidal anti-inflammatory agent ATX Code M01AH21
Pharmacological properties Pharmacodynamics After oral administration diacerein is rapidly absorbed from the gastrointestinal tract and is completely deacetylated to rhein. Simultaneous administration of the drug with food increases the bioavailability by 25%. The maximum concentration (C max ) reached after rhein 144 minutes in plasma. Plasma half-life period of 255 minutes. Rhein Communication albumin almost 100%. In single dose of 50 mg C max reaches 3.15 mg l. Repeated taking the drug With max increases due to the accumulation of the drug. Rhine excreted by the kidneys in unchanged form (20%) and a glucuronide (60%) and sulphate (20%). Rhine crosses the placental and blood-brain barriers.
Primary and secondary osteoarthritis.
Hypersensitivity of the components of the drug or a high sensitivity to the anthraquinone drugs (such as laxatives). Children’s age (18 years). Pregnancy, lactation. Severe liver or kidney failure, intestinal obstruction, inflammatory bowel disease. Lactose intolerance, lactase deficiency, malabsorption glyukozogalaktoznaya.
Patients with irritable bowel lower divisions drug is given only in special cases.
Dosage and administration
Standard intake: 1 capsule 2 times a day (morning and evening, after a meal). The halotestin side effects should be swallowed whole without chewing, and drink water. The effect of the treatment can be expected after 2-4 weeks. Artroker is used continuously for a long time or courses lasting at least 4 months. The duration of the break between treatments establishes doctor.
In case of hypersensitivity to the drug may experience allergic reactions of varying degrees, rash, pruritus. In the initial period of the drug may temporarily be a phenomenon on the part of the digestive system: diarrhea, nausea, vomiting, abdominal pain. In this case, the dose should be reduced to one capsule a day.
It may be the intense coloration of urine from yellow to brown (depending on pH), which does not require dose reduction (cancellation) of the drug.
If overdose is possible diarrhea, weakness. In case of overdose or accidental medication children should consult a doctor. Treatment is symptomatic.
Interaction with other drugs :
. Artroker recommended not to be taken with drugs that affect the consistency of the bowel contents (eg, high in fiber)
Antacids reduce the absorption of the drug. At simultaneous reception with antibiotics or chemotherapeutic drugs affecting the intestinal microflora, may increase the frequency of adverse events on the part of the intestine.
Special instructions :
The duration of treatment depending on the result achieved might be prolonged. In the period prior to the development of therapeutic effect Artroker can be taken together with other non-narcotic analgesics and non-steroidal anti-inflammatory drugs. A periodic monitoring blood counts, liver enzymes, urinalysis. When renal function deterioration doctor should decide to reduce the dose of the drug or its cancellation.
Product form :
. halotestin side effects 50 mg
10 halotestin side effects in an aluminum blister strip or aluminum / aluminum.
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